Long Live the (Hypertext) Link!
If you write, I dunno . . a couple thousand words a month (a week?) on your blog, you’re naturally attuned to subtle shifts in the style and usage of the English language.
Like . . . no one 
underlines anymore, because it’s confused for a hypertext link.
See what I mean?
What does that leave?
Essentially, boldface, italics, and ALL-CAPS.
Least Worst
At least to Web old-timers like me, all-caps has a negative association, because it comes across as SHOUTING.
Italics is fine, except that it can’t be used too close to quoted material, which I like to also set off with italics.
Bottom line?
I find myself relying on a combination boldface/italic, which seems excessive only until you realize that prose is noisier and busier online.
